Abstract：Objective: To study the effect of Nimodipine combined with donepezil hydrochloride on cognitive impairment and quality of life in patients with cerebral infarction. Methods: 82 patients of cognitive impairment after cerebral infarction who received therapy from Jan. 2016 to Dec. 2016 in our hospital were selected. According to random number table, The patients were divided into the observation group and the control group, 41 cases of each group. Patients in the control group were treated with donepezil hydrochloride, and patients in the observation group were treated with nimodipine on this basis. The clinical efficacy and NIHSS score, Montreal Cognitive Assessment Scale (MoCA) score, motor function scale (Fugl-meyer score) and adverse reactions were compared between the two groups before and after treatment. Results: After treatment, the clinical efficiency of the observation group was significantly higher than that of the control group 92.68%(38/41) vs 73.17% (30/41) (P<0.05); The NIHSS score in observation group was significantly lower than that in control group (3.87±1.33) vs (5.56±1.85) score (P<0.05); The MoCA score in observation group was significantly higher than that in control group (26.53±5.71) vs (22.02±5.47) score (P<0.05); The Fugl-meyer score in observation group was significantly higher than that in control group (84.57±6.13) vs (73.13±6.02) score (P<0.05); The total incidence of adverse reactions in observation group was lower than that in control group 14.63% (6/41) vs 41.46% (17/41) (P<0.05). Conclusion: Nimodipine combined with donepezil hydrochloride is effective in the treatment of cognitive impairment of cerebral infarction. It can obviously improve the nerve defect, cognitive function and motor function of the patients, and improve the quality of life of the patients with high safety. The effect is better than the use of donepezil alone. It is worthy of application.
王建峰, 张晨红, 王婉, 吕日琅. 尼莫地平联合盐酸多奈哌齐对脑梗死认知障碍患者的疗效及对生活质量的影响[J]. 河北医学, 2018, 24(8): 1273-1276.
WANG Jianfeng, ZHANG Chenhong, WANG Wan, et al. Effect of Nimodipine Combined with Donepezil Hydrochloride on Cognitive Impairment and Quality of Life in Patients with Cerebral Infarction. HeBei Med, 2018, 24(8): 1273-1276.
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2018, Vol. 24 
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