Abstract：Objective: To investigate the risk factors of hypertensive disorders of pregnancy (HDP) and the association between gestational hypertension and target organ damage. Methods: From Oct 2015 to Oct 2017, 1468 pregnancy women were enrolled in Xintai People's Hospital. Clinical data, such as age, pre-pregnancy body mass index(BMI), blood pressure and family history of HDP were collected. Left ventricular hypertrophy was assessed by left ventricular mass index (LVMI) using cardiac color Doppler ultrasound. Estimate glomerular filtration rate (eGFR) was calculated base on the level of serum creatinine. Their clinical data were analyzed and logistic regression model was made to determine risk factors of HDP. Multivariate linear regression analysis was made to determine the independent influencing factors of LVMI and eGFR. Results: The prevalence of HDP was 5.18% among 1468 pregnancy women. Age (OR=3.071, 95%CI: 1.583-5.957), pre-pregnancy BMI (OR=1.213, 95%CI: 1.064-1.382), pre-pregnancy anxiety (OR=1.684, 95%CI: 1.164-2.435) and family history of HDP (OR=2.678, 95%CI: 1.446-4.957) were independent risk factors of HDP (P<0.05). Twenty-four-hour systolic blood pressure and diastolic blood pressure were positively correlated with LVMI (correlation coefficients were 0.736 and 0.702, respectively, all P<0.001) and negatively correlated with eGFR (correlation coefficients were -0.696 and -0.633, respectively, all P<0.001). After adjustment for confunders, 24-hour systolic blood pressure and diastolic blood pressure were independently and significantly associated with LVMI and eGFR (all P<0.05). Conclusion: Advanced age, pre-pregnancy BMI, pre-pregnancy anxiety and family history of HDP were independent risk factors of HDP. However, HDP played a crucial and independent role of target organ damage.
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2018, Vol. 24 
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