Abstract：Objective: To explore the levels changes of serum Th1/Th2 cytokines and AFP in patients with advanced hepatocellular carcinoma (PHC) before and after transcatheter arterial chemoembolization (TACE) and their clinical significance. Methods: 95 cases of PHC patients hospitalized in our hospital were divided into the TACE group (n=58, given TACE treatment) and the venous group (n=37, given intravenous chemotherapy). The lesion reduction degree and the levels of serum Th1/Th2 cytokines and AFP before and after TACE were compared between the two groups. Results: The total reduction rate of lesion in the TACE group was significantly higher than that in the venous group (P<0.05). The serum AFP level, the AFP positive rate and the levels of serum interleukin-4 (IL-4) and interleukin-10 (IL-10) were significantly decreased after treatment in the two groups (P<0.05) while the levels of interferon-γ (IFN-γ) and interleukin-2 (IL-2) were significantly increased (P<0.05). The levels changes of serum AFP and Th1/Th2 cytokines in the TACE group were higher than those in the venous group (P<0.05). The positive expression rate of IL-10 in the TACE group was significantly lower than that in the venous group (P<0.05). Conclusions: TACE treatment can effectively control the disease condition of advanced PHC and regulate Th1/Th2 balance disorders, and the levels of serum Th1/Th2 cytokines and AFP can be used as important indicators for efficacy evaluation.
王碧玉, 王露莹, 羊文芳. 中晚期PHC患者TACE术前后血清Th1/Th2细胞因子AFP水平的变化及意义[J]. 河北医学, 2018, 24(6): 1028-1031.
WANG Biyu, WANG Luying, et al. Change and Significance of Levels of Serum Th1/Th2 Cytokines and AFP before and after TACE in Advanced PHC Patients. HeBei Med, 2018, 24(6): 1028-1031.
2018, Vol. 24 
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