Abstract：Objective: To investigate the relationship between epidermal growth factor receptor (EGFR) gene mutation and the expression of Ki-67 protein in lung adenocarcinoma with micropapillary structure (MPP) and its clinical significance. Methods: The clinical data of MPP lung adenocarcinoma in our hospital from 2013 to 2017 were collected. The mutation of EGFR gene in 80 patients was detected by gene sequencing, and the expression of Ki67 was detected by immunohistochemistry.Results: Of the 80 specimens, 50 cases were detected EGFR mutation, the total detection rate was 62.5%. Among them, the mutation rate of EGFR gene was high in non smoking and female. It was not related to age, tumor size, metastasis and staging; the expression rate of Ki67 protein was 63.8%. The expression of Ki67 and sex, age, smoking history, tumor size, lymph node metastasis and staging were all. No correlation; EGFR and Ki67 expression were positively correlated. Conclusion: The mutation rate of EGFR in MPPAC is higher than that in other subtypes of lung adenocarcinoma. It is highly expressed in female, non smoking, tumor size over 3cm. The expression rate of Ki67 in MPPAC was higher than that in other subtypes of lung adenocarcinoma, and it was highly expressed in patients with tumor diameter greater than 3cm. In MPPAC, the expression of EGFR gene and Ki67 protein is positively correlated. The positive rate of both of them is related to the size of tumor. It is speculated that the mutation of EGFR gene leads to abnormal overexpression of Ki67 and promotes the proliferation of tumor cells. In the Sanya group with different MPP ratios, the EGFR gene mutation rate and the positive rate of Ki67 protein expression were not related to the proportion of MPP.
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2018, Vol. 24 
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