Abstract：Objective: To study clinical research of Ilaprazole sequential in treatment of peptic ulcer and the effects on serum gastrin and gastrin gene expression. Methods: 80 patients of peptic ulcer who received therapy from March 2015 to March 2016 in our hospital were selected as research objects. According to the draw method divided into control group and experimental group, all the 40 cases. The control group was treated with routine treatment, oral omeprazole, Clarithromycin Capsules, Furazolidone Tablets. while the observation group was treated with Ilaprazole sequential, Ilaprazole Enteric-coated Tablets, Clarithromycin Capsules, Furazolidone Tablets oral. Then symptom relief, healing time, healing rate, HP eradication time, HP eradication rate, serum gastrin and gastrin gene expression, adverse reaction rate, treatment effect of two groups were compared. Results: The symptom relief, healing time, healing rate, HP eradication time and HP eradication rate in the experimental group were significantly lower than those in the control group[92.50%(37/40)vs75.00%(30/40),(6.93±1.35)week vs(3.29±0.74)week,92.50%(37/40)vs75.00%(30/40),(7.49±1.67)d vs(10.86±2.45)d,95.00%(38/40)vs75.00%(30/40)](P<0.05); The gastrin and gastrin gene expressions were significantly lower than those in the control group [(24.57±6.04)pmoL/L vs(28.09±6.37)pmol/L,(0.13±0.02)pmol/L vs(0.25±0.05)pmoL/L] (P<0.05); The total incidence of adverse reactions was significantly lower than that of the control group[10.00%(4/40)vs42.50%(17/40)](P<0.05); The total effective rate was significantly higher than that of the control group[95.00%(38/40)vs70.00%(28/40)] (P<0.05). Conclusion: Ilaprazole sequential is well for peptic ulcer, which can reduce the local inflammatory reaction of ulcer, reduce gastric acid secretion, reduce serum gastrin level and gastrin gene expression, and can significantly improve therapeutic efficacy and safety of medication.
吴大威, 杨玉双, 崔青志, 王立维, 张清, 王静, 刘立奇. 艾普拉唑序贯治疗消化性溃疡的临床研究及对血清胃泌素与胃泌素基因表达的影响[J]. 河北医学, 2018, 24(5): 791-793.
WU Dawei, YANG Yushuang, CUI Qingzhi, et al. Clinical Research of Ilaprazole Sequential in treatment of Peptic Ulcer and the Effects on Serum Gastrin and Gastrin Gene Expression. HeBei Med, 2018, 24(5): 791-793.
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2018, Vol. 24 
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