The Prophylactic Effect of Propofol on the Preventive Effect of Cesarean Section Postoperative Adverse Reactions of Hemabate and the Influence on Hemodynamics
CAO Xiuling, XU Mingjun
Beijing Obstenc and Gynecological Hospital Affiliated to Capital Medical University, Beijing 100026, China
Abstract：Objective: To analyze the preventive effect of propofol on cesarean section hemabate adverse reactions and influence on hemodynamics. Methods: 86 cases of caesarean section were received therapy from January 2017 to October 2017. According to the random table method, those patients were divided into control group and research group, 43 cases in each group. Both groups were given epidural anesthesia, intravenous infusion of 10U oxytocin after childbirth, and in the palace injection of 250μg hemabate. The patients in the study group were immediately given intravenous infusion of 3mg.kg/min propofol, while the control group was intravenously injected with the same amount of normal saline. The adverse reactions, hemodynamics and operation before and after operation were compared between the two groups. Results: The incidence of flushing, chest tightness, nausea and vomiting, dizziness and headache in the study group were lower than those in the control group (P<0.05). Before operation, there was no difference in heart rate (HR), diastolic pressure (DBP), systolic pressure (SBP), respiratory frequency (RR) and oxygen saturation (SpO2) in two groups (P>0.05). After operation, two groups of HR, DBP, SBP and RR all increased, SpO2 decreased correspondingly, and the amplitude of change in the study group was smaller than that in the control group (P<0.05). There was no difference in bleeding volume, extubation time and operative time between the two groups (P>0.05). Conclusion: The effect of propofol on prevention of adverse reactions that cesarean section of hemabate, can reduce maternal discomfort. It is more conducive to the stability of hemodynamics, and has certain guiding value for clinical work.
曹秀玲, 徐铭军. 丙泊酚对剖宫产术中欣母沛不良反应的预防效果及对血流动力学的影响[J]. 河北医学, 2018, 24(5): 752-754.
CAO Xiuling, XU Mingjun. The Prophylactic Effect of Propofol on the Preventive Effect of Cesarean Section Postoperative Adverse Reactions of Hemabate and the Influence on Hemodynamics. HeBei Med, 2018, 24(5): 752-754.
[1] Dawe RE, Bishop J, Pendergast A, et al. Cesarean delivery rates among family physicians versus obstetricians: a population-based cohort study using instrumental variable methods[J]. CMAJ Open,2017,5(4):E823~E829. [2] Ravindran R, Sajid B, Ramadas KT, et al. Intrathecal hyperbaric bupivacaine with varying doses of buprenorphine for postoperative analgesia after cesarean section: a comparative study[J]. Anesth Essays Res,2017,11(4):952~957. [3] 吴寒冰,艾玲,钟少平,等.宫腔球囊联合欣母沛在前置胎盘剖宫产术中止血的临床观察[J].中华全科医学,2015,13(2):238~240. [4] 韩艳,张俊娣.高危二次剖宫产出血患者宫体注射欣母沛治疗的效果及不良反应[J].中国计划生育和妇产科,2016,8(12):40~43. [5] 安洁,徐铭军,王宇祺,等.腰麻剖宫产术中产妇血流动力学变化规律和特点[J].中国医刊,2016,51(8):19~23. [6] Rashid MR, Najeeb R, Mushtaq S, et al. Comparative evaluation of midazolam, dexmedetomidine, and propofol as intensive care unit sedatives in postoperative electively ventilated eclamptic patients[J].Anaesthesiol Clin Pharmacol,2017,33(3):331~336. [7] 王晓娟,魏雪洋,谢玲娟.欣母沛联合宫腔填纱治疗前置胎盘剖宫产产后出血的疗效[J].中国性科学,2016,25(11):120~122. [8] 袁明峰,陈宇.右美托咪定预防剖宫产术中欣母沛不良反应的效果[J].江苏医药,2015,41(21):2597~2598. [9] 王家强,缪长虹,陈家伟.丙泊酚的脑保护作用及其机制研究进展[J].中国新药与临床杂志,2016,35(8):538~541. [10] 谢延红,肖志荣,陈岚,等.腰麻硬膜外联合麻醉与硬膜外麻醉对剖宫产患者血流动力学的影响[J].现代生物医学进展,2015,15(31):6132~6135. [11] 朱雷,赵志斌,丁孟谣,等.丙泊酚与异氟醚麻醉对妇科腹腔镜手术患者血流动力学及应激反应的影响[J].现代生物医学进展,2015,15(22):4351~4354.
2018, Vol. 24 
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