Abstract：Objective: To analyze the effect of genital tract group B streptococcus (GBS) infection in late pregnancy on pregnancy outcomes. Methods: 500 pregnant women in late pregnancy (35~37 weeks) were divided into the positive group (positive GBS bacterial culture) and the normal group (no GBS infection) according to the results of GBS bacterial culture and drug sensitivity test. The positive rate of GBS infection was statistically analyzed. In the positive group, patients who were willing to accept the clinical treatment were included into the medication group, and they were treated according to the results of drug sensitivity analysis, while patients who had concerns about medication and were not given any drug treatment were included into the non-medication group. The pregnant outcomes were compared between groups. Results: In the 500 cases of pregnant women in late pregnancy, GBS was positive in 84 cases (positive group), accounting 16.8%, including 55 cases in the medication group and 29 in the non-medication group. A total of 106 strains of GBS were detected, and their resistance rates to penicillin, ampicillin and erythromycin were high, while the resistance rates to clindamycin, ceftriaxone and vancomycin were low. The rate of cesarean section showed the normal group < the medication group < the non-medication group (29.8%, 43.6%, 51.7%), and the natural delivery rate showed the normal group > the medication group > the non-medication group (65.6%, 50.9%, 41.4%), with statistically significant differences between groups (P<0.05). There was no significant difference between the normal group and the medication group in the incidence rates of amniotic fluid pollution, intrauterine infection, fetal distress, premature delivery, postpartum hemorrhage and puerperal infection (P>0.05), but the incidence rates of above-mentioned complications in the non-medication group were significantly higher than those in the normal group and the medication group (P < 0.05). There was no significant difference between the normal group and the medication group in the incidence rates of neonatal sepsis, neonatal GBS infection, neonatal pneumonia and neonatal asphyxia (P > 0.05), but the incidence rates of above-mentioned adverse perinatal outcomes in the non-medication group were significantly higher than those in the normal group and the medication group (P<0.05). Conclusion: The risk of genital tract GBS infection is high in late pregnancy. It can cause the increase of cesarean section rate, incidence rates of complications and adverse perinatal outcomes. Targeted medication can improve pregnancy outcomes.
张倩, 严涵, 张凤. 妊娠晚期生殖道B族溶血性链球菌(GBS)感染及对妊娠结局的影响分析[J]. 河北医学, 2018, 24(4): 608-611.
ZHANG Qian, YAN Han, ZHANG Feng. Effect of Genital Tract Group B Streptococcus (GBS) Infection in Late Pregnancy on Pregnancy Outcomes. HeBei Med, 2018, 24(4): 608-611.
2018, Vol. 24 
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