Shuanghua Qingre Granules Combined with Ambroxol Hydrochloride in the Treatment of Geratic Chronic Tracheitis and Effects on the Serum IL-6 IL-17 TNF-α MMP-9 levels
CHEN Lulu, et al
Qingdao Central Hospital, Shandong Qingdao 266042, China
Abstract：Objective: To study the curative efficacy of Shuanghua Qingre granules combined with ambroxol hydrochloride in the treatment of geratic chronic tracheitis and its effects on the serum interleukin-6(IL-6), interleukin-17 (IL-17), tumor necrosis factor-α(TNF-α) and matrix metalloproteinase-9(MMP-9) levels. Methods: 80 patients of geratic chronic tracheitis admitted from April 2014 to April 2015 in our hospital were selected as research objects and divided into the observation group (n=40) and the control group (n=40). Both groups of patients were treated with conventional treatment after admission, including asthma, spasmolysis, fever etc. The control group was treated with ambroxol hydrochloride injection on the basis of conventional therapy, every time 30mg, 2 times a day, while the observation group was treated with Shuanghua Qingre granules on the basis of control group, once for 20g, 3 times a day. Both groups were treated for 2 weeks. Then the curative effect, clinical symptoms (cough, wheezing, dyspnea) disappearance time, changes of IL-6, IL-17, TNF-α, MMP-9 levels, pulmonary function FEV1, FEV1/FVC before and after treatment were compared between two groups. Results: The total effective rate of observation group was significantly higher than that of the control group [95.00% (38/40) vs 75.00% (30/40)] (P<0.05); The disappearance time of cough, wheezing, breathing difficulties were significantly shorter in the observation group than those of the control group [(2.80±0.67)d vs (5.38±1.20)d, (4.58±1.01)d vs (8.93±1.21)d (4.02±0.90)d vs (6.78±1.35)d] (P<0.05); the serum IL-6, IL-17, TNF-α, MMP-9 levels were significantly lower than those of the control group [(8.02±2.12)μg/L vs (12.32±2.30)μg/L, (15.87±3.42)pg/L vs(19.36±4.02)pg/L, (16.30±4.21)ng/L vs (23.76±4.60)ng/L, (0.30±0.12)ng/L vs (0.50±0.14)ng/L] (P<0.05); the FEV1,FEV1/FVC were significantly higher than those of the control group [(57.36±9.32)% vs (50.37±8.97)%,(66.86±7.80)% vs (61.92±6.84)%] (P<0.05). Conclusion: Effect of Shuanghua Qingre granule combined with ambroxol hydrochloride in treatment of senile chronic bronchitis is significantly better than the treatment with single, ambroxol hydrochloride injection. It can significantly improve the clinical symptoms and lung function of the patients, and reduce the level of serum IL-6, IL-17, TNF-α and MMP-9.
2018, Vol. 24 
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