Abstract：Objective: To investigate the effect of Salvia miltiorrhiza Ligustrazine Injection in the treatment of Refractory hypertension in elder in serum CRP and homocysteine. Methods: 90 cases with refractory hypertension in our hospital were selected and divided into 2 groups, 44 cased in the control group received irbesartan and hydrochlorothiazide treatment, 44 cases in the treatment group received more with Salvia miltiorrhiza Ligustrazine Injection treatment, a total of 14 days treatment. Changes of laboratory indexes were compared to explore the clinical effect and mechanism of the Salvia miltiorrhiza Ligustrazine Injection in the treatment of Refractory hypertension. Results: After 14 days of treatment, diastolic blood pressure and systolic blood pressure in 2 groups were significantly decreased than before(P<0.05), and the average blood pressure in the treatment group was lower than the control group(P<0.05). After 14 days of treatment, the total effective rate of the treatment group was significantly higher than the control group(P<0.05). Before treatment, two groups of CRP, Hcy, whole blood viscosity, whole blood low shear viscosity was no significant difference after treatment, CRP, Hcy, whole blood viscosity, whole blood low shear viscosity of treatment group improvement were better than the control group, there was significant difference between two groups. (P<0.05). Conclusion: Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection adjuvant therapy can significantly improve serum CRP and homocysteine levels in patients with refractory hypertension, and it has good clinical therapeutic effect.
马建林, 王晓红, 李春梅, 陈永新, 谢德霞, 张翠芳. 丹参川芎嗪注射液辅助治疗对顽固性高血压患者血清CRP及同型半胱氨酸水平影响研究[J]. 河北医学, 2018, 24(2): 228-232.
MA Jianlin, WANG Xiaohong, LI Chunmei, et al. Study on the Effect of Salvia Miltiorrhiza Ligustrazine Injection in the Treatment of Refractory Hypertension in Elder in Serum CRP and Homocysteine. HeBei Med, 2018, 24(2): 228-232.
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2018, Vol. 24 
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