加用匹多莫德治疗对扁桃体炎患儿血清炎性因子水平和免疫功能的影响

doi:10.3969/j.issn.1006-6233.2018.01.011

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摘要 目的: 探讨加用匹多莫德治疗对扁桃体炎患儿血清炎性因子水平和免疫功能的影响。方法: 选取2015年1月至2016年8月我院收治的240例扁桃体炎患儿为研究对象,盲法随机数字表法分为对照组(实施常规药物治疗,n=140)及观察组(在对照组基础上另加用匹多莫德治疗,n=100),观察治疗前后两组血清炎性因子[白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)]、免疫功能[T细胞亚群(CD3+、CD4+、CD8+)]、临床症状改善情况[发热持续时间、咳嗽持续时间、扁桃体红肿时间]、治疗1年后复发次数及再入院率。结果: 治疗前两组IL-4、IL-6、IFN-γ、CD3+、CD4+、CD8+、发热持续时间、咳嗽持续时间、扁桃体红肿时间相较无显著差异(P>0.05);治疗后两组IL-4、IL-6、CD8+较治疗前显著降低,IFN-γ、CD3+、CD4+显著升高,发热持续时间、咳嗽持续时间、扁桃体红肿时间较治疗前明显缩短,且治疗后观察组各项指标变化(除CD4+)较对照组明显,差异有统计学意义(P<0.05)。治疗后1年观察组复发次数、再入院率较对照组明显少、低,差异显著(P<0.05)。结论: 加用匹多莫德治疗扁桃体炎患儿临床疗效明确,其通过有效调节机体血清炎性因子水平及免疫功能指标变化,继而达到改善患儿临床症状及改善患儿预后效果的目的。

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	吴云斐

关键词 ：扁桃体炎, 匹多莫德, 炎性因子, 免疫功能

Abstract：Objective: To investigate the effect of additional use of pidotimod therapy on levels of serum inflammatory factors and immune function in children with tonsillitis. Methods: 240 cases of children with tonsillitis admitted in our hospital from January 2015 to August 2016 were enrolled in the study, and they were divided into control group (treated with routine drugs, n=140) and observation group (additionally treated with pidotimod therapy, n=100) by the random number table method. The serum inflammatory factors [interleukin -4 (IL-4), interleukin -6 (IL-6), interferon γ (IFN- γ)], the immune function [T cell subsets (CD3+, CD4+, CD8+)], the relief of clinical symptoms (duration of fever, duration of cough, duration of tonsil inflammation), recurrent frequency after 1 year of treatment and readmission rates in the two groups were observed before and after treatment. Results: There were no significant differences in IL-4, IL-6, IFN-γ, CD3+, CD4+ and CD8+, duration of fever, duration of cough and duration of tonsil inflammation between the two groups before treatment (P > 0.05). After treatment, IL-4, IL-6 and CD8+ in the two groups were significantly decreased, IFN-γ, CD3+ and CD4+ were significantly increased, the duration of fever, duration of cough and duration of tonsil inflammation were significantly shortened, and the changes of the above indexes (except CD4+) were more obvious in the observation group than the control group (P < 0.05). After 1 year of treatment, the recurrent frequency and readmission rate of the observation group were significantly less or lower than those of the control group (P < 0.05). Conclusion: The additional use of pidotimod therapy is effective in the treatment of children with tonsillitis. It can relieve the clinical symptoms and improve the prognosis of children through effective regulation of serum inflammatory factors and immune function.

Key words： Tonsillitis Pidotimod Inflammatory factor Immune function

基金资助:江苏省卫生厅资助基金项目,(编号:20130165)

引用本文:

吴云斐. 加用匹多莫德治疗对扁桃体炎患儿血清炎性因子水平和免疫功能的影响[J]. 河北医学, 2018, 24(1): 47-50.
WU Yunfei. Effect of Additional Use of Pidotimod Therapy on Levels of Serum Inflammatory Factors and Immune Function in Children with Tonsillitis. HeBei Med, 2018, 24(1): 47-50.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.01.011 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I1/47

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