Abstract：Objective: To study the effect on proliferation of KW-2478 to Eca109 and KYSE-150 esophageal cancer cell line, SGC-7901 gastric cancer cell line, HepG2 hepatoma cell line and MCF-7 breast cancer cell in vitro. And to observe the effect of KW-2478 to HL-7702 normal hepatocytes. Methods: HL-7702, Eca109, KYSE-150, SGC-7901, MCF-7 and HepG2 cell lines were cultured in vitro, give different concentrations of KW-2478, MTT assay test cell proliferation after 24h and 48h. Results: After 24h and 48h different concentrations of KW-2478 to the tumor cells, the proliferation of five tumor cells were reduced in dose-dependent and time-dependent, and showed dose and time interaction on Eca109 cells and HepG2 cells, but HL-7702 was not significantly affected. Conclusion: KW-2478 have inhibitory effect to Eca109, KYSE-150, SGC-7901, MCF-7 and HepG2 cells, and had no significant effect on the proliferation of HL-7702 normal hepatocytes.
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2018, Vol. 24 
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