Abstract：Objective: To investigate the relationship of BPV evaluation index: the actual average variation (ARV) and standard deviation (SD) of the pros and cons through the analysis of newly diagnosed patients with essential hypertension blood pressure variability (BPV) and urinary albumin (MA). Method:A total of 223 of primary hypertension patients were selected, averaged (50.9±12.1) years old. all the patients were not taking antihypertensive drugs, according to microalbuminuria divided into positive-MA group (71 case) and negative-MA group (152 case). Baseline data, 24h mean systolic and diastolic pressure, nocturnal systolic and diastolic blood pressure, daytime systolic and diastolic blood pressure, and SD and ARV of the corresponding period were compared, to analyze the relationship between MA and mean blood pressure, SD, ARV, and so on. Result:The SD (24h SBP, dSBP, nSBP), ARV (24hSBP, dSBP) in positive-MA group were higher than the negative-MA group, and there was statistical significance (P<0.05); but SD , ARV of diastolic blood pressure, ARV of nighttime systolic blood pressure are no significant difference between the two groups (P>0.05). ②Logistic regression analysis showed that 24h mean systolic blood pressure, SD of diurnal systolic pressure ,SD of nocturnal systolic blood pressure , ARV of 24h systolic blood pressure were independent risk factors of MA. Conclusion: Blood pressure variability is an independent risk factor for predicting early renal function impairment, and SD and ARV can be used to assess blood pressure variability.
杨静,张小玲,苏浩,严激,张灿,游杨扬. 初诊原发性高血压患者血压变异性与尿微量白蛋白的相关性研究[J]. 河北医学, 2017, 23(12): 2061-2064.
YANG Jing, ZHANG Xiaoling, SU Hao, et al. Relationship between Blood Pressure Variability and Microalbuminuria in patients with Primary Hypertension. HeBei Med, 2017, 23(12): 2061-2064.
[1] Vladimir A,Boulatov, Aud Stenehjem,et al.Association between albumin:creatinime ratio and 24-hour ambulatory blood pressure in essential hypertension[J].Am Hypertens , 2001, 14(4): 338~344. [2] Emmanuel A,Andreadis,Gerasimos D,et al.Automated office blood pressure is associated with urine albumin excretion in hypertensive subjects[J].Am Hypertens,2012, 25(9): 969~973. [3] 焦坤,冯玉宝,苏平.血压变异性与心血管疾病的研究进展[J].中国循环杂志,2016,31(5):518~520. [4] 李慧妍,刘越,尹新华.血压变异性与靶器官损害关系的研究进展[J].中国急救医学,2016,36(8):758~762. [5] Madden JM,OFlynn AM,Dolan E,et al.Short-term blood pressure variability over 24 h and target organ damage in middle-aged men and women[J].Hum Hypertens , 2015, 29(12):719~725. [6] Hans-Henrik Parving,Frederik Persson,Peter Rossing . Microalbuminuria: A parameter that has changed diabetes care[J].Diabetes Res Clin Pract, 2015, 107(1): 1~8 . [7] Francesca Viazzi, Francesca Cappadona, Roberto PontremoLi . Microalbuminuria in primary hypertension: a guide to optimal patient management[J].Nephrol , 2016,29(6):747~753. [8] 陈云,张媛媛,刘海亭.高血压患者尿微量白蛋白/肌酐比值与动态血压水平及血压变异性的关系[J].中国循证心血管医学杂志,2016,8(1):75~77. [9] Mule G, calcaterra I, Costanzo M, et al. AVerage real variability of 24-h systolic blood pressure is associated with microaibuminuria in patients with primary hypertension[J].Hypertens, 2016,30(3):164~170.
2017, Vol. 23 
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