Abstract：Objective: To evaluate the clinical curative effect and safety of Bozhi Glycopeptide Injection in the treatment of large areas of psoriasis vulgaris. Methods: One hundred and six cases of patients with large areas of psoriasis vulgaris were randomly divided into the control group and treatment group, 53 cases in each group. The control group was given A citretin capsule 30mg, qd, orally, on the basis of the control group, the experimental group was treated with Shen Qi Bozhi Glycopeptide Injection 4ml, qd, intravenous drip. Before and after treatment, compared between the two groups of patients with serum tumor necrosis factorα (TNF- α), interleukin 6(IL-6) , interleukin 17A(IL-17A) levels, interleukin-22(IL-22), interferonγ(INF-γ) , vascular endothelial growth factor (VEGF) , soluble E selectin (sE-slelctin) , soluble intercellular adhesion molecule -1 (sICAM-1) , efficiency of treatment and incidence of adverse reactions. Results: After treatment, serum levels of TNF-α, IL-6, IL-17A, IL-22, INF-γ,VEGF, sE-slelctin, sICAM-1 in the control group respectively were(91.65±12.87) pg/mL,(89.76±11.08)pg/mL,(16.46±1.55)pg/mL,(45.23±6.11)pg/mL,(16.52±2.47)pg/mL,(152.34±20.08)pg/mL,(43.29±5.78)ng/mL,(117.21±10.29)μg/L,, the levels of the above indicators in the experimental group respectively were (49.57±7.02) pg/mL, (58.46±7.66)pg/mL,(10.75±1.23)pg/mL,(38.23±5.01)pg/mL,(9.75±1.32)pg/mL,(123.12±12.54)pg/mL,(29.55±4.21)ng/mL,(98.75±12.13)μg/L, compared with the control group, the serum levels of TNF-α, IL-6, IL-17A, IL-22, INF-γ, VEGF, sE-slelctin, sICAM-1 were lower in the experimental group (P<0.05). The treatment efficiency of the experimental group (90.58%) was significantly higher than that of the control group (67.92%) (P<0.05). There was no significant difference in the incidence of adverse reactions between the 2 groups (P > 0.05). Conclusion: The Bozhi Glycopeptide Injection can significantly reduce the serum levels of TNF-α, IL-6, IL-17A, IL-22, INF-γ, VEGF, sE-slelctin and sICAM-1 in patients with large areas of psoriasis vulgaris, inhibit angiogenesis, improve clinical efficacy, and have high clinical efficacy and safety.
王应权. 薄芝糖肽注射液治疗大面积寻常型银屑病的临床疗效及安全性评价[J]. 河北医学, 2017, 23(12): 1994-1996.
WANG Yingquan. The Research on Clinical Curative Effect and Safety of Bozhi Glycopeptide Injection in the Treatment of Large Areas of Psoriasis Vulgaris. HeBei Med, 2017, 23(12): 1994-1996.
2017, Vol. 23 
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