Abstract：Objective: To evaluate the clinical efficacy of mesenchymal stem cells in patients with ankylosing spondylitis (AS). Methods: A retrospective study was conducted on 82 patients with AS from May 20 to May 2017. Among them, 42 patients were treated with mesenchymal stem cells as observation group and 40 patients treated with anti-rheumatic drugs as control group (BASF) score and the brachial ankylosis disease activity index (BASDAI) score were measured before and after treatment, and the changes of liver function, blood pressure index, nighttime pain VAS score, Bath ankylosing spondylitis function index (BASFI) score and Bath ankylosing spondylitis disease activity index Variety. Results: After treatment, the blood transfusion count (RBC), white blood cell count (WBC), platelet count (PLT) and hemoglobin (HB) were observed in [(3.20 ± 0.24) × 1012/L], [(893.65 ± 121.85 (106.84±7.68)×109 / L],[(106.84 ± 12.35) g / L], which was significantly different from that before treatment (t = 9.40,30.14,7.08,5.34; P < (AST) and total bilirubin (TBIL) were significantly higher than those in the control group (P <0.05) (T = 3.44, 3.44, 3.02; P <0.05). The patients in the observation group were significantly higher than those in the control group (P <0.05) After treatment, VAS score, BASFI score and BASDAI score were significantly better than before treatment (P <0.05), compared with the control group was also statistically significant (P <0.05). Conclusion: AS patients with mesenchymal stem cell therapy can effectively improve the patient's blood and liver function levels, and can effectively alleviate the clinical symptoms of patients, improve spinal function, the effect is remarkable, worthy of clinical promotion.
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2017, Vol. 23 
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