Abstract：Objective: To investigate the clinical effect and safety of dexmedetomidine combined with morphine epidural analgesia after cesarean section. Methods: From January 2014 to September 2015, 60 cases with cesarean section were randomly divided into 2 groups, each with 30 cases. After cesarean section, the control group was injected with morphine 1 mg by epidural tube, and the patients in the study group were injected with morphine 1 mg+ and 1 g/kg by dexmedetomidine. The postoperative analgesia and sedative effect of the two groups were observed and compared. The changes of MAP fluctuation, SpO2, heart rate, nausea and vomiting, urinary retention, pruritus and chills in the two groups were compared. Results: The analgesic and sedative effects of the two groups were evaluated. After surgery 2h, 4h, 8h, 24h the pain classification and Ramsay score at all stages of improvement of the study group were better than the control group (P < 0.05), the difference was statistically significant. There were 2 cases of nausea and vomiting, 1 case of urinary retention, 2 cases of skin pruritus and 1 case of shivering, and the incidence of adverse reactions was 20% in the study group. The study group was obviously better than the control group (P < 0.05), the difference was statistically significant(P＜0.05). Conclusion: After the cesarean section analgesia, the combination of dexmedetomidine can achieve satisfactory analgesic and sedative effect, and the rate of adverse reactions is low, which provides a good clinical basis for the rational use of drugs in women.
[1]徐国铖,沈琦.几种镇痛药物在剖宫产术后静脉镇痛中的效果比较[J].深圳中西医结合杂志,2016,26(1):24~26. [2] 原峰,李宁,孙申.不同剂量右美托咪定预防剖宫产术患者脊椎-硬膜外麻醉后寒战的效果[J].中华麻醉学杂志,2015,35(2):165~167. [3] 程松鹤,何绮桃,曾丽蓉.麻醉前静注右美托咪定对腰硬联合麻醉下剖宫产产妇与新生儿的影响[J].中国医药导刊,2015,7:715~716. [4] 李荣华.右美托咪定在腰麻-硬膜外联合麻醉下剖宫产术的临床应用[J].医学理论与实践,2015,28(9):1227~1228. [5] 刘先保,张春芳,陈涛.右美托咪定联合舒芬太尼对剖宫产术后镇痛效果影响[J].临床医学工程,2015,22(3):296~297,300. [6] R Schumann.J Hudcova.Dexmedetomidine infusion during surgery in patients with a pheochromocytoma acta[J].Anaesthesiologica Scandinavica,2010,54(3):393~394. [7] 王淑伟.不同剂量右美托咪定治疗剖宫产患者术中寒战效果观察[J].现代中西医结合杂志2015,23:2592~2594. [8] 邓超,吴畏.右美托咪定对全麻剖宫产患者血流动力学及应激反应的影响[J].四川医学,2015,2:191~194. [9] Yingjun, She Zhiyi, Zhang Xingrong.Caudal dexmedetomidine decreases the required concentration of levobupivacaine for caudal block in pediatric patients: a randomized trial[J].Paediatric Anaesthesia,2013,3(12):1205~1212. [10] 吴丽丽,王爱民.静脉注射右美托咪定对剖宫产手术术中恶心呕吐的影响[J].齐齐哈尔医学院学报,2015,29:4432~4433. [11] 薄玲,曹耀辉.右美托咪定治疗腰麻-硬膜外麻醉后患者寒战的疗效观察[J].中国基层医药,2014,21(18):2839~2841.
2017, Vol. 23 
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