Abstract：Objective: To explore the expression and clinical significance of cyclooxygenase-2 and proliferating cell nuclear antigen in bladder leukoplakia.Methods: The expressions of cyclooxygenase-2 and proliferating cell nuclear antigen in 26 cases of bladder leukoplakia and 26 cases of normal urothelium and 26 cases of bladder carcinoma were detected by immunohistochemistry S-P method. Results: Two kinds of protein expression in normal urothelial were occasional, the expression of cyclooxygenase-2 in bladder leukoplakia was 46.15% and bladder cancer was 76.92%, the expression of proliferating cell nuclear antigen in bladder leukoplakia was 53.84% and bladder cancer was 69.23%. Conclusion: The expression of cyclooxygenase-2 and proliferating cell nuclear antigen is correlated with the occurrence of bladder leukoplakia, and the occurrence and progression of bladder leukoplakia may be related to the occurrence of bladder cancer.
2017, Vol. 23 
冀公网安备13080202000677号