Abstract：Objective: To investigate the expression of PTTG and VEGF-C in laryngeal squamous cell carcinoma and the relationship with the pathological features. Methods: Immunohistochemistry and RT-PCR were adopted to detect the expression of PTTG and VEGF-C in 60 cases of laryngeal squamous cell carcinoma and 32 cases of para-carcinoma tissue. Results: The expression of PTTG and VEGF-C in laryngeal squamous cell carcinoma were significantly higher than that in para-carcinoma tissue (P<0.01). In laryngeal squamous cell carcinoma, the expressions of PTTG and VEGF-C were associated with differentiation, Lymph node metastasis and clinical stage (P<0.01). Conclusion: PTTG and VEGF-C might play an important role in the development of laryngeal squamous cell carcinoma. PTTG and VEGF-C might be prognostic factor of lymph node metastasis
高立生, 高珊, 徐勤, 刘双, 刘晓东. 喉鳞癌组织中PTTG VEGF-C的表达及与临床病理特征的相关性[J]. 河北医学, 2017, 23(4): 656-658.
Gao Lisheng, et al. Expression of PTTG and VEGF-C in Laryngeal Squamous Cell Carcinoma and its Correlation with Clinicopathological Features. 河北医学, 2017, 23(4): 656-658.
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2017, Vol. 23 
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