Abstract：Objective: To investigate the effect of probiotics in the eradication of Helicobacter pylori. Methods: 122 cases of Hp positive patients were selected and were randomly divided into three groups. Group A were received quadruple chemotherapy for 14 days, group B were receved bifidobacterium tetravaccine tablets combinated with quadruple chemotherapy for 14 days, group C were receved bifidobacterium tetravaccine tablets 14 days. Results: Group A and group B were better than group C in the eradication rate of Hp, and group B receivce the highest eradication rate of Hp. Group B possess absolute advantage in the prevention of reinfection rate of Hp. Conclusion: The application of Bifidobacterium quadruple viable tablets alone can not improve the eradication rate of Hp, and its combination with quadruple therapy can significantly improve the rate of Helicobacter pylori eradication, and can significantly reduce the long-term Hp reinfection rate
张冰, 王艳玲, 李炳庆, 贾兰芳. 四联疗法联合益生菌治疗幽门螺杆菌疗效观察[J]. 河北医学, 2017, 23(4): 613-615.
ZHANG Bing, WANG Yanling, LI Bingqing, et al. Effect of Probiotics Combinated with Quadruple Chemotherapy in the Eradication of Helicobacter Pylori. 河北医学, 2017, 23(4): 613-615.
[1] 王巧敏,刘怀昌,李妙根.益生菌联合改良序贯疗法治疗初治失败幽门螺杆菌感染的疗效研究[J].临床内科杂志,2015,32(8):550~552. [2] Aiba Y,Nakano Y,Koga Y,et al. A highly acid-resistant novel strain of Lactobacillus johnsonii No. 1088 has antibacterial activity, including that againstHelicobacter pylori, and inhibits gastrin-mediated acid production in mice[J].Microbiologyopen,2015,4(3):465~474. [3] Khalil MA,El-Sheekh MM,El-Adawi HI,et al.. Efficacy of microencapsulated lactic acid bacteria in Helicobaterpylorieradication therapy[J].Res Med Sci,2015,20(10):950~957. [4] Srinarong C,SiramoLpiwat S,Wongcha-um A,et al. Improved eradication rate of standard triple therapy by adding bismuth and probiotic supplement forHelicobacter pyloritreatment in Thailand[J].Asian Pac Cancer Prev,2014,15(22):9909~9913. [5] Enany S,Abdalla S. In vitro antagonistic activity of lactobacillus casei againstHelicobacter pylori[J].Braz Microbiol,2015,46(4):1201~1206. [6] Homan M,Orel R,et al.Areprobioticsuseful inHelicobacter pylorieradication[J].World Gastroenterol,2015,21(37):10644~10653. [7] Oh B,Kim BS,Kim JW,et al. The effect of probioticson gut microbiota during the helicobacter pylori eradication: randomized controlled trial[J].Helicobacter,2015,10(23) :12270. [8] Gong Y,Li Y,Sun Q. Probioticsimprove efficacy and tolerability of triple therapy to eradicateHelicobacter pylori: a meta-analysis of randomized controlled trials[J].Int Clin Exp Med,2015,8(4):6530~6543. [9] Park JM,Jeong M,Kim EH,et al. Omega-3 polyunsaturated fatty acids intake to regulateHelicobacter pylori-associated gastric diseases as nonantimicrobial dietary approach[J].Biomed Res Int,2015,9(3):712363. [10] Dore MP,Goni E,Di Mario F. Is there a role for probioticsin helicobacter pyloriTherapy[J].Gastroenterol Clin North Am,2015,44(3):565~575.
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