Abstract：Objective: To study the changes of serum BALP, CA125, NSE, CEA and CYFRA21-1 levels in patients with lung cancer bone metastases and the effects of radiotherapy on serum levels of PINP and β-CTX.Methods: Thirty-six patients with bone metastases from advanced lung cancer were included in our study. Forty patients with lung cancer without bone metastasis were selected as bone metastases group. BALP, CA125, NSE and CEA were measured in all patients. And CYFRA21-1 tumor markers such as levels. The levels of PINP and β-CTX in the patients with lung cancer bone metastasis before and after radiotherapy were also measured.Results: The levels of BALP, CA125, NSE, CEA and CYFRA21-1 in lung cancer patients with bone metastasis were significantly higher than those without metastasis (P <0.05). The level of serum PINP before radiotherapy was higher than that after radiotherapy, and there was significant difference (t = 5.233, P <0.05) (0.56 ± 0.41) ng / mL,which was slightly higher than that after radiotherapy (0.41 ± 0.13) ng / mL, there was no statistically significant difference (t = 1.266, P> 0.05). The level of serum PINP in patients with radiotherapy before radiotherapy was significantly higher than that before radiotherapy (110.13 ± 80.99 ng / mL vs 48.16 ± 18.91 ng / mL, t = 6.029, P <0.05) (0.48 ± 0.32) ng / mL, which was significantly higher than that after radiotherapy (0.29 ± 0.15) ng / mL, and there was significant difference (t = 4.609, P <0.05). The level of PINP in patients with bone metastases from lung cancer before radiotherapy (102.47 ± 78.75) ng / mL was significantly higher than that after radiotherapy (43.29 ± 18.28) ng / mL, and there was significant difference (t = 7.023, P < (0.52 ± 0.34) ng / mL was significantly higher than that after radiotherapy (0.34 ± 0.18) ng / mL, with statistical significance (t = 4.601, P <0.05). There were 11 cases of NR, 12 cases of PR and 13 cases of CR in 36 cases of lung cancer with bone metastatic chemotherapy. The effective rate was 69.44%.Conclusion: Combined detection of BALP, CA125, NSE, CEA and CYFRA21-1 in patients with bone metastases of lung cancer is of great clinical significance. In addition, serum PINP and β-CTX are helpful in judging the progression of bone metastasis. Both of them have a good monitoring effect in the evaluation of metastatic radiotherapy, which is of great significance to prolong the survival time of patients with bone metastasis of lung cancer and improve the therapeutic effect.
朱礼. 肺癌骨转移血清肿瘤标志物水平及放疗对血清PINP和β-CTX水平的影响分析[J]. 河北医学, 2017, 23(3): 394-397.
ZHU Li. Serum Levels of Tumor Markers and Radiotherapy on Serum Levels of PINP and β-CTX in Lung Cancer Patients with Bone Metastasis. HeBei Med, 2017, 23(3): 394-397.
[1] Lumachi F,Santeufemia DA,Conte AD,et al.Carboxy-terminal telopeptide(CTX)and amino-terminal propeptide(PINP)of type I collagen as markers of bone metastases in patients with non-small cell lung cancer[J].Anticancer Res,2013,33(6):2593~2596. [2] Barmadas A,Manso L,de la Perdra C,et al.Bone turnover markers as predictive indicators of outcome in patients with breast cancer and bone metastases treated with bisphosphonates:Results from a 2-year multicentre observational study(ZOMAR study)[J].Bone,2014,7(68C):32~40. [3] 徐欣,黄仁华,周狄,等.血清β-CTX和OST在骨转移放疗中的临床研究[J].临床肿瘤学杂志,2013,18(1):25~29. [4] 孙燕,管忠震,廖美琳,等.肺癌骨转移诊疗专家共识(2014版)[J].中国肺癌杂志,2014,17(2):57~72. [5] 李殿波,姜格宁.肺肿瘤标志物及碱性磷酸酶对肺癌骨转移早期诊断的临床意义[J].医学综述,2015,22(8):1487~1488. [6] TANG C,LIU Y,QIN H,et al.Clinical significance of serum BAP,TRACP 5b and ICTP as bone metabolic markers of bone metastasis screening in lung cancer patients[J].Clin Chim Acta,2013,42(6):102~107. [7] 吴京,谢惠英,蔡梦洁,等.肺癌骨转移患者6项骨代谢指标的变化[J].检验医学,2016,31(10):904~906. [8] 刘洋,贺贵福,赵义,等.SPECT/CT联合CEA、Cyfra-211、NSE诊断肺癌骨转移的价值[J].中国老年学杂志,2015,35(24):7081~7083.
2017, Vol. 23 
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