Abstract：Objective: To investigate whether EGF,TGF2β,bFGF,TNF-α,CRP and PEDF affect diabetic retinopathy. Methods: Serum EGF,TGF2β,bFGF,TNF-α,CRP and PEDF were detected by ELISA in control, NDR, NPDR and PDR groups. Results: The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRP in NDR,NPDR and PDR groups were higher than control group, while PEDF was lower (P<0.05). The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRP in NPDR and PDR were higher than NDR group while PEDF was lower (P<0.05). The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRPin PDR were higher than NPDR group, while PEDF was lower (P<0.05). Conclusion: Hyperglycaemia induced VEGF,TGF2β,bFGF,TNF-α,CRP levels and reduced PEDF, which aggravated the pathological changes in retina.
张艳莉, 赵岐, 黄强. 糖尿病视网膜病变患者血清相关细胞因子水平的研究[J]. 河北医学, 2017, 23(3): 391-393.
ZHANG Yanli, ZHAO Qi, et al. Study on the Expression of Related Cytokines in the Serum of Patients with Diabetic Retinopathy. HeBei Med, 2017, 23(3): 391-393.
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2017, Vol. 23 
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