Abstract：Objective: To investigate the effects of atorvastatin combined with trimetazidine for the treatment of patients after the in vivo Caspase-1 and IL-18 expression changes. Methods: 100 cases of patients with coronary heart disease (CHD) admitted in our hospital from July 2013 to July 2015 were randomly divided into observation group and control group; the control group was treated with trimetazidine treatment, observation group were treated with atorvastatin combined with trimetazidine treatment sibutramine; patients after the treatment, assessment, intervention at the end of the observation before and after treatment in patients with blood rheology blood lipid levels, learning condition, and the levels of Caspase-1 and IL-18 in serum. Results: The effective rate of the observation group was significantly higher than the control group, and the difference has statistical significance (P<0.05); After treatment, The TC, TG, HDL-C and LDL-C levels of Patients were significantly decreased (P<0.05), and the observation group was significantly lower than that of control group (P<0.05); red blood cell hematocrit and plasma viscosity the whole blood viscosity and low shear rate and high shear rate of whole blood viscosity patients was significantly reduced (P<0.05), and the observation group was significantly lower than that of control group (P<0.05);The Caspase-1 levels of patients two groups were significantly decreased (P<0.05), and the observation group was significantly lower than that of control group (P<0.05); IL-18 in two groups significantly decreased (P<0.05), and the observation group was significantly lower than that of control group (P<0.05). Conclusion: The trimetazidine and atorvastatin on the prognosis of patients with CHD can improve the blood lipid and blood rheology in patients with learning condition, reduce the levels of Caspase-1 and lower the level of IL-18, it has high value in clinical application.
袁小蓉, 徐苹, 杨博. 阿托伐他汀联合曲美他嗪对冠心病患者Caspase-1和IL-18表达水平的影响[J]. 河北医学, 2017, 23(2): 180-183.
YUAN Xiaorong, XU Ping, YANG Bo. Atorvastatin Combined with Trimetazidine on the Expression Level of Caspase-1 and IL-18 of patients with CHD. HeBei Med, 2017, 23(2): 180-183.
2017, Vol. 23 
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