The Anesthesia Advantage of Intranasal Dexmedetomidine(DEX) Application Used in Pediatric Anesthesia Induction Period Undergoing the Lower Abdomen and Lower Extremity Surgery
CAO Xuefeng, et al
The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China
Abstract：Objective: To observe the anesthesia advantage of intranasal dexmedetomidine(DEX) application used in pediatric anesthesia induction period undergoing the lower abdomen and lower extremity surgery. methods: We enrolled 40 patients who were undergoing the general anesthesia for lower abdomen and lower extremity elective surgery, which were randomly devided into A(n=20) and B(n=20) groups , intranasal dexmedetomidine 1ug/kg 30min before operation in group A, physiological saline instead in group B. 1mg /kg propofol was infused intravenously every time who could not smoothly into the operating room of children as well as the induced intolerance to oxygen mask of children. 1. Record each patient general information respectively; 2. Sedation status when separating from their parents and mask induction scores were assessed, the dose of propofol during induction period were recorded ; 3. Mean arterial pressure(MAP) ,Heart rate(HR) and saturation of pulse oximetry (SPO2) were recorded at different time points as follows: baseline values were recorded before intranasal dexmedetomidine (T0), transferred into operation room (T1), immediately inserting the laryngeal mask (T2) , at 5 min after intubation(T3) and operation immediately (T4); 4. The time of operation, induction , extubation and anesthesia awake were recorded; 5. The adverse events such as hypoxemia , bradycardia , reflection of tussis , laryngismus and tachycardia were recorded. Results: 1.The general situation have no statistical significance (P>0.05); 2. Compared with group B, sedation status when separating from their parents are higher in A group , the consumption of propofol are less than B group , mask induction scores are lower in A group(P<0.05); 3. The influence of two groups on the MAP, HR and SPO2 are difference (P<0.05), the A group was relatively stable than the B group. Compared with T0 , the MAP, HR and SPO2 of group A at all points are no difference (P>0.05), the MAP of group B at T1 are lower, at T2 are higher significantly (P<0.05) . The HR of group B at T1,4 are higher significantly (P<0.05). The SPO2 of group B at T1 are lower significantly (P<0.05). 4. The time of operation, extubation and anesthesia awake have no statistical significance (P>0.05), the induction time of A group are shorter than B group(P<0.05); 5. The two groups have no hypoxemia and bradycardia , compared with group B, the emergence reflection of tussis , laryngismus and tachycardia are lower in group A(P<0.05). Conclusion: Intranasal dexmedetomidine(DEX) application used in pediatric anesthesia induction period undergoing the lower abdomen and lower extremity surgery could significantly reduce induction time and reduce adverse reaction, increase comfort and safety of children in the transfer process, it has a relatively stable hemodetomidine during induction.
曹雪峰, 姜亚男, 赵亮, 刘旭东, 刘玉伶, 董天鑫, 李燕. 右美托咪定滴鼻在儿科下腹及下肢手术中麻醉诱导期的应用优势[J]. 河北医学, 2017, 23(1): 65-68.
CAO Xuefeng, et al. The Anesthesia Advantage of Intranasal Dexmedetomidine(DEX) Application Used in Pediatric Anesthesia Induction Period Undergoing the Lower Abdomen and Lower Extremity Surgery. HeBei Med, 2017, 23(1): 65-68.
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2017, Vol. 23 
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