Abstract：Objective: To investigate the effects of mesalazine by different administration routes and serum levels of tumor necrosis factor (TNF-α), interleukin-10 (IL-10) and interleukin-17 (IL-17) in treatment of active ulcerative colitis (UC). Methods: Totally 60 eligible patients were selected and randomly divided into observation group and control group, with 31 patients in observation group and 29 patients in control group. The control group was given mesalazine sustained-release granules once for 1g; while the observation group was given mesalazine enemas once for 4g. After 4 weeks of treatment, the clinical efficacy was observed, and the serum levels of TNF-α, IL-10, and IL-17 were measured. Results: The observation group had significantly higher overall response rate than the control group (93.55% vs. 79.31%)(P<0.05).After treatment, both groups had significantly lower serum levels of TNF-α and IL-17 and significantly higher serum IL-10 level than those before treatment (P<0.05).The observation group had significantly greater improving extents of serum levels of TNF-α, IL-10, and IL-17 than the control group (P<0.05). Conclusion: Mesalazine used by enema in treatment of UC has a significant clinical efficacy, and it is beneficial to the balance between inflammatory factors and antiinflammatory factors.
李晓玲. 美沙拉秦不同给药途径治疗活动期溃疡性结肠炎的疗效及对血清炎性因子的影响[J]. 河北医学, 2016, 22(10): 1595-1597.
LI Xiaoling. Effects of Mesalazine by Different Administration Routes on Active Ulcerative Colitis and the Influence on Serum Inflammatory Factors. 河北医学, 2016, 22(10): 1595-1597.
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2016, Vol. 22 
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